That was definitely in the right direction. The inspiration to my question came from AI research, and deep neural networks specifically. I fantasised that there might be some ratios or general shapes of organization networks that cultivate emergent properties particularly well. VSM certainly appears related to this notion.
Perhaps the most practical way to dimension the system is to ensure that self-organization can take place in a good and healthy way. Make sure that all organs are formed and then allow adaptation, while weeding out any tumors that may appear.
Knowing your “Why?”, as Sinek puts it, is probably an essential element in all of this. Allowing adaptation, while pushing and evolving towards one consistent greater goal.